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Sanofi Group Senior Scientist, Route Scouting in Waltham, Massachusetts

Position Overview:

The Process Chemistry, Route Scouting team part of the CMC organization in Sanofi is responsible for the design and preliminary development of NDA route for commercial manufacturing of Active Principle Ingredients. We strongly believe innovation is an important driver to reach success and we focus a large part of our activity on developing new synthetic routes, new concepts and technologies to provide drug substances in a more efficient, more affordable, environmentally benign and intrinsically safe way.

To reinforce our expertise in organic chemistry, we are looking for a highly motivated individual to join our Chemical Development group as a Senior Scientist specialized in route scouting. Under the direction of the Head of Process Chemistry, the primary responsibility of this role is to perform and oversee development activities, focusing on NDA Route Scouting and NDA Route Process Development while managing internal as well as outsourced laboratory activities. Depending on projects, this role may also oversee the activity of one or more collaborators.

Key Responsibilities:

  • Design novel synthetic pathway for products entering development. Knowledge of digital tools (CASP programs like Scifinder-n or Documentary database like Reaxys etc.).

  • Conduct early stage route scouting in laboratory to demonstrate synthetic viability.

  • Use all imaginable chemistry tools and methods to develop new synthetic pathways (photochemistry, biochemistry, flow chemistry, electrochemistry, on-line analysis, High Throughput Screening, structural analysis (NMR, UPLC/MS)).

  • Analyze experimental data to drive synthetic experimental plans.

  • Assist in the design, planning and execution of multi-step experimental studies to provide safe, efficient, robust and scalable processes.

  • Investigate scale-up of optimized reactions.

  • Depending on projects, manage outsourced laboratory activities: establishing RFP, supervising activities at CDMOs, validating reports for outsourced activities.

  • Integrate project teams by working in close collaboration with analytical chemists, process engineer, pilot plant experts and project manager within the Pharmaceutical Development group.

  • Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development report, project discussion and presentation.

  • Draft and review technical reports, external publications and patent applications.

Basic Qualifications:

  • PhD in organic or synthetic chemistry with a minimum of 4years of experience within the field of Route Scouting, Chemical Process Design and/or Early Process development or Master’s degree with a minimum of 8 years of relevant industry experience.

  • Demonstrated expertise in modern synthetic organic chemistry.

  • Knowledge in at least one of the following areas: Analytics, Biocatalysis, Flow Chemistry, High Throughput Experiments, Process Engineering.

  • Excellent communication skills.

  • Ability to operate with flexibility in a changing environment and with tight deadlines.

Preferred Qualifications:

  • Knowledge of digital tools, Data Analysis, DOE and/or Thermo-kinetic Modeling.

  • Experience in the management of subcontractors.

  • Strategic and innovative thinker with a track record of fresh insightful thinking by developing creative approaches to processes and practices.

  • French language skills.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.