Sanofi Group Scientist, Gene Therapy in Waltham, Massachusetts
We are seeking a highly motivated, enthusiastic, and PhD level scientist to be part of our team focused on gene therapy research in the Genomic Medicine Unit. The successful candidate will contribute to the development of novel gene therapy treatments for rare blood disorders and liver centric genetic diseases. The incumbent will have significant experiences in molecular biology, virology, and gene therapy.
Generation and optimization of viral vectors for novel gene therapy.
Production and purification of recombinant baculoviral and/or AAV vectors.
Transfection and infection in insect as well as mammalian cell lines.
Production and purification of gene therapy drug substance at large scale.
Development and optimization of conditions for large-scale research grade production of viral vectors.
Data analysis, record keeping and troubleshooting experimental problems.
Develop and maintain a culture of teamwork and collaboration.
PhD in the field of Virology, Molecular Biology, Microbiology, Cell biology, Biochemistry or related fields OR
Master’s Degree plus minimum 3 years of relevant research experience in an academic or biopharmaceutical setting OR
Bachelor’s Degree plus minimum 6 years of relevant research experience in an academic or biopharmaceutical setting.
Extensive experience in molecular biology, virology, and recombinant DNA technology is required.
Extensive experience in cell cultures is required.
Extensive experience in DNA and RNA purification is required.
Working experience with baculovirus and/or AAV vectors is plus.
Working experience with adherent and suspension cell cultures at large scale is plus.
Working experience with tangential flow filtration and chromatographic methods is plus.
Effective communication and organizational skills.
Meticulous in cell culture, laboratory techniques, and record keeping.
Ability to learn quickly and work independently.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.