Sanofi Group Cell Culture Process Development Senior Scientist in Waltham, Massachusetts
The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best in class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced cell culture development professional with experience in viral vector production to join the Genomic Medicine Cell Culture Process Development Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Culture Development group within Sanofi operates with the mission to develop robust, scalable and innovative viral vector cell culture processes for Sanofi’s genomic medicine pipeline.
The successful candidate will be responsible for managing pilot scale bioreactor operation, modification of bioreactor configuration, bioreactor characterization and process automation to ensure successful development, scale-up and tech transfer of viral vector manufacturing process
Develop operation strategies for pilot scale bioreactors.
Manage routine operation and maintenance of pilot scale bioreactors.
Lead bioreactor characterization for successful scale-up and scale-down modelling.
Lead modification of bioreactor configuration.
Develop process automation strategy.
Evaluate and implement latest process technologies.
Contribute to project, technical, and strategic teams as appropriate.
Effectively manage a multi project development portfolio.
Make strong technical strategic contributions to cross functional development project teams to ensure efficient and timely execution of deliverables.
Establish and drive innovation in furthering scientific and process understanding to enhance viral vector productivity and quality.
Plan resources for supported projects to ensure timely delivery of department objectives.
Serve as a subject matter expert in one or more selected areas of cell culture development and support the entire upstream development portfolio.
Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.
Contribute to manuscript and patent writing for external publications and patent applications.
PhD degree in Chemical Engineering or related discipline with a minimum of 4 years of relevant industry experience or a master’s degree with a minimum of 8 years of experience or a bachelor’s degree with a minimum of 10 years of experience.
Strong knowledge of fundamental engineering principles relevant to cell culture process.
Experience in operating bench scale and pilot scale bioreactors.
Excellent communication skills.
Experience in managing one or more junior staff either directly or as a matrix team lead.
Experience in the biotech/pharmaceutical industry within a cell culture role and an excellent understanding of the theory and practice of cell culture process development.
Experience managing cross functional team and initiatives.
Experience in the development of HeLa producer cell line production processes and/or HEK AAV transient transfection production.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.