Sanofi Group Scientist in Toronto, Ontario

Scientist, Upstream Bioprocess R&D

Reference #: 2466092

Department: BRD Upstream

Location: Toronto, Ontario

About Sanofi Pasteur:

Sanofi Pasteur, the vaccines division of Sanofi, is the largest company in the world devoted entirely to human vaccines. Our driving goal is to protect people from infectious diseases by creating safe and effective vaccines. Our company distributes more than 1 billion doses of vaccine each year, making it possible to vaccinate more than 500 million people across the globe. Sanofi Pasteur offers the broadest range of vaccines in the world, providing protection against 20 bacterial and viral diseases.

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Job Summary:

The Incumbent of this position will be Scientist joining the Upstream platform of our Bioprocess R&D (BRD) department. Reporting to the Platform leader, Upstream Bioprocess R&D, the Scientist – Upstream BRD will be responsible for the development of processes for the generation of clinical trials material (proteins and viruses) from microbial and animal cell culture for use as vaccines. The scientist will interface between Research, Analytical Research and Development, and Manufacturing Technology, and is accountable to fulfill the specific scientific, technical and compliance-related roles for assigned projects as defined by the BRD Development Leadership Team. The scientist will supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks.

Key accountabilities will include:

  • Responsible for specific scientific, technical and compliance aspects of assigned project, ensure that objectives are met. Plan and supervise execution of product development activities (develop, improve, scale-up processes, and provide material and documentation for seed and cell bank production, pre-clinical and clinical trials) within platform for the project to ensure scientific and technical excellence. Supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks.

  • To ensure good scientific and technical leadership within BRD and the platform, keep abreast of the current developments in relevant scientific and technical disciplines and ensure current developments are implemented when appropriate.

  • Prepare internal and external presentations, patent filings, research manuscripts and review articles as required.

  • Manage and develop competencies of direct reports. Ensure compliance of direct reports with GxP and other quality and documentation requirements, such as preparation of SOPs, BPRs and validation reports. Provide leadership for data input, standardized formats, database creation and management, and implementation of corporate standards. Ensure that direct reports are well-informed about current policies, new directions and training initiatives. Ensure teamwork and empowerment of all direct reports. Coach and motivate staff to perform efficiently and achieve objectives on time, on budget.

  • Share information and harmonize development within BRD, and other departments such as Research, Manufacturing Technology, Industrial Operations, Quality Operations, Regulatory Affairs, Clinical/Medical as necessary. Ensure good teamwork and provide high quality deliverables, such as Technical reports, development reports within agreed timeframes. Support regulatory submission by participating in preparation of regulatory submission documents (CTA, IND, CTD).

  • In depth knowledge of experimental work and data analysis. Working knowledge of computer skills, scientific writing and presentations, supervisory/management/people development, communication skills, innovative thinking, and a familiarity with strategic planning, balanced judgment, risk analysis and budget process is required.

  • Works with the policies, procedures and regulations as required by the Company and under Occupational Health and Safety Act. Supervises and monitors compliance with employment and health and safety legislation to ensure that employees work within the policies, procedures and regulations.

Platform Specific Accountabilities:

  • Development of media and nutrient feeds for the cultivation of microbes, animal cells and viruses for vaccine candidate supply. Development of process for GMP manufacturing of master and working cell bank and virus seeds. Development of scalable bioreactor process for GMP manufacturing of vaccine candidates including the selection of operating mode (batch, fed batch, continuous, biphasic, etc) and conditions for production scales of up to 200 L. Selection of scalable primary recovery approaches for bioreactor harvest concentration, cell disruption, and product recovery using combinations of filtration, centrifugation, homogenization, sonication, and chemical treatments.

  • Use of analytical methods for measuring cell densities and biomass, culture medium analysis, protein analysis, immunological detection of proteins (ELISA, Western blotting, etc), HPLC, virus titration by CCID or plaque assay, flow cytometry, and PCR.

  • Support for GMP manufacturing including process technology transfer, equipment selection and validation, process flows, vendor and raw materials selection, aseptic processing, and sterilization.

  • Application of biochemical engineering principles including mass and heat transfer, fluid dynamics, process control, process simulation and modelling, and equipment design. Use of advanced computer software to support bioreactor process control and data acquisition, DOE, process modelling and simulations, computational fluid dynamics, and experimental data analysis.

Required Qualifications:

  • PhD (Molecular Biology, Biochemistry, Microbiology, Virology, Biochemical Engineering) with

  • 3-5 years’ industry experience in vaccine development or relevant field (in addition or apart from academic-related work).

  • In-depth knowledge of animal cell culture, viral vaccines, microbial cultivation, bioreactor operation, primary recovery processes, process analytical technology and quality by design.

  • Working knowledge of microbiology, biochemistry, chemical engineering principles, bioreactors, and cell and viral culture.

  • In-depth knowledge of experimental design, execution and data analysis.

  • Strong computer, scientific writing and presentations skills.

  • Proven supervisory/management/people development experience is required.

  • Highly organized and excellent communication, interpersonal and team leadership skills.

  • Familiarity with strategic planning and budget process.

Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to a ttract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request.

Applications received after the official close date will be reviewed on an individual basis.

NOTE: Internal applicants are required to notify their manager of their application.

Sanofi, Empowering Life

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Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life