Sanofi Group Manager Scientist in Meriden, Connecticut
Analytical and Formulation Development
Reports to: Deputy Director Analytical Formulations
Personnel Managed: Analysts, Professionals
Responsibilities: Candidate will contribute directly to the development, improvement, and management of recombinant protein vaccines. As a member of the Analytical Formulations team, the candidate will lead the development and optimization of analytical assays to characterize vaccine targets, design experiments and studies to trouble shoot and investigate protein stability, and analyze and trend data for vaccine life cycle management. Candidate will accomplish these tasks in a laboratory setting and through collaborations both internal and external.
Function as a lead and subject matter expert in investigations to support vaccine development and manufacturing.
Develop assays to monitor manufacturing processes and characterize proteins and vaccines using both immunological and biophysical methods and techniques such as Enzyme-linked Immunosorbent Assay (ELISA), Bi-layer Interferometry (Octet), Differential Scanning Fluorometry (DSF), Infrared spectroscopy (IR), Capillary Electrophoresis (CE), and Ultra Performance Liquid Chromatography (UPLC).
Transfer newly developed assays to the Quality Control and/or Process Development groups as required.
Design and execute studies to evaluate changes to manufacturing processes, equipment and/or site, and to evaluate the stability of novel protein candidates.
Identify stability and formulation problems and evaluate potential solutions and improvements independently.
Participate on cross-functional teams to manage and facilitate projects.
Manage and train analysts on procedures and systems.
Adhere to company policies and maintain documentation and records of laboratory data and results.
Provide and write status updates, status reports, assessments, development reports, procedures, and publish manuscripts in peer reviewed journals where appropriate.
Maintain a knowledge of the scientific literature.
Present ideas, concepts, and findings internally and externally and represent the company at national and international scientific conferences.
Education, Qualifications, and Experience/Skills:
Ph.D. degree in Biochemistry or relevant field including Biophysical Chemistry, Biology, Biomedical Engineering or combination of experience and training that is equivalent.
2-5+ years of hands on post-doctoral experience in the characterization of vaccines and biologics in a pharmaceutical or biotechnology industry setting preferred.
Experience is biophysical and biochemical characterization of proteins and a familiarity with state of the art biophysical and biochemical assays such as DSC, DLS, DSF, Bi-layer Interferometry, and UPLC. Experience in assay validation is a plus.
Familiarity with cGMPs and/or vaccine manufacturing.
Experience in managing multiple projects and laboratory personnel.
Excellent verbal and written communication skills.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.
With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.
Sanofi, Empowering Life