Sanofi Group Senior Scientist- Framingham/MA in Framingham, Massachusetts
A highly motivated structural biologist is sought to join our structural biology team in Protein Engineering within Sanofi US Biologics Research department. We use leading edge crystallography, cryoEM, and computational modeling tools to support different project needs from Sanofi’s multi-targeting multi-modality research pipeline. Our structural biology team has a great track record of publications in the area of biologics characterization, antibody engineering and multi-specific antibodies.
Work closely with experienced scientists in a dynamic and highly collaborative global environment.
Plan with project teams to address their questions of biologics candidate with customized structural biology tools.
Deliver high quality structural information of antibody antigen complex using crystallography, cryoEM, and HDX-MS as needed.
Provide structure based analysis and rational design with computational programs to optimize biologics candidate, including epitope analysis and comparison, structure-function relationship, developability risk mitigation, stability, humanization/simianization, and affinity variation.
Ph.D. in protein crystallography, cryoEM, or equivalent with less than 5 years of postdoctoral or industrial experience.
Proven in-depth knowledge and expertise in protein structural biology and biochemistry demonstrated preferably through principal authorship in peer-reviewed publication(s).
Specifically, candidate must have extensive experience in protein construct optimization, protein purification, data collection and structure determination either with crystallography or cryoEM with strong protein chemistry skills.
Expertise in common crystallography or cryoEM software and refinement at low resolution are required.
Strong and consistent written and oral communication ability in professional settings.
Experience with biochemical biophysical assays/techniques (DLS, MALS, DSF, HPLC, AUC) and mass spectrometry.
Knowledge of antibody structures, experience with CRO or project management are also desirable.
Experience with developability prediction and engineering.
Familiarity with lab robotics and automation and other protein biophysical characterization techniques is preferred.
Programming skill with Python, Perl, MATLAB, etc is a plus.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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