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Sanofi Group Senior Principal Scientist, Immunotoxicology in Framingham, Massachusetts

Job overview

Sanofi is seeking an innovative immunologist, with strong expertise in cellular immunology assays, who is highly-motivated to help address safety concerns related to immunomodulatory drugs in our portfolio. The successful candidate will report to the Global Head of Investigative Toxicology and be responsible for devising and executing plans to address immune-related safety issues at all stages in development, with specific focus prior to drug candidate nomination. The candidate will work collaboratively with colleagues across Sanofi sites worldwide to develop immunosafety assays, strategies, and models, and support application of such within the Sanofi portfolio. Participation in external immunotoxicology consortia and representing Sanofi at relevant scientific venues is also a component of this role.


  • Support development of strategies to manage safety risks for immunomodulatory candidates in collaboration with Sanofi subject matter experts and Preclinical Safety project team members.

  • Design mechanistic experiments and coordinate supporting Investigative Toxicology resources to address immune-related safety issues. Author reports to support inclusion of results in white papers or regulatory submissions as needed.

  • Develop necessary assays and tools for assessing impact on immune function and apply these assays and tools for both screening compounds for safety liabilities and investigation of mechanisms of toxicity. Ensure scientific rigor, including designing appropriate validation plans and testing strategies. Promote and support use of these models by project teams.

  • Oversee incorporation of immune components in in vitro microphysiological system models, including strategy for evaluation and qualification.

  • Participate in external immunotoxicology consortia and symposia to keep current with industry trends and regulatory evolution in the immunotoxicology field. Represent Sanofi interests, maintaining high ethical and scientific standards. Author external presentations and manuscripts to contribute to scientific advancement of the immunotoxicology field.

Requirements & Qualifications

PhD in immunology with a minimum of 8 years of experience working in the pharmaceutical or biotechnology industry, beyond postdoctoral experience, is required. Knowledge and direct expertise and experience in immunology and immunological assays is required. Experience in pharmacology, toxicology, drug development, or regulatory safety are a plus. Established record of scientific contribution in peer-reviewed journals and scientific symposiums, and excellent verbal and written communication skills are also required.

Terms of employment

Occasional domestic and international travel to Sanofi Research and Development sites and scientific meetings. Availability to start in 4Q2019.

What makes this position unique?

The candidate will be part of a growing Investigative Toxicology group at Sanofi and have the opportunity to help shape and guide research in the immunotoxicology field. This is an excellent opportunity for career growth and leadership in the exciting, expanding field of immunotoxicology, and the global scope will provide the candidate with a rich, diverse work experience.

Benefits of working in this role

The candidate will

  • Be part of an active, innovative scientific group

  • Develop leadership and subject matter expertise in immunotoxicology

  • Have diverse opportunities to collaborate globally

  • Be highly recognized for successes

  • Receive excellent benefits and compensation.

Location information

The position is based in Framingham, MA.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.