Sanofi Group Senior Associate Scientist, Upstream Development in Framingham, Massachusetts
The Senior Associate Scientist position is part of the Upstream team in the drug substance function within the global Manufacturing Science & Technology (MSAT) and is based at the biologics hub in Framingham, MA. The MSAT mission is to enable the reliable supply of SC (Specialty Care) medicines by providing expert technical and scientific support to their licensure, ongoing commercial manufacturing, and life-cycle management activities.
The drug substance function within MSAT is the owner of Life Cycle Management (LCM) of DS Processes within Sanofi biologics manufacturing network. We deliver innovative, robust, and cost-effective next generation processes and provide commercial manufacturing support. The function is responsible for tech transfer activities including process fit-gap assessment, process validation, prepare dossier sections, & PAI support to enable launch of new and LCM products. Our expansive portfolio covers 17 products, 5 modalities, 3 expression systems within 12 internal and external global sites in US and EU. We will be supporting launch of 20 new products in next 5 years including monoclonal and multi-specific antibodies, fusion protein, antibody-drug conjugate, synthorins and nanobodies. In recent years we have successfully established second-generation manufacturing process with continuous process platform. We are pursuing future innovations such as digital labs, factory of future and advanced analytics based process understanding and control.
POSITION OVERVIEW /KEY RESPONSIBILITIES:
The Senior Associate Scientist will be a key contributor in the Upstream group.
The successful candidate will apply scientific principles and utilize cell culture, bioreactor, and separation technologies to: improve current commercial and develop next-generation processes of monoclonal antibodies and recombinant proteins, with responsibilities spanning bench and pilot-scale process development & characterization, as well as support of technology transfer to manufacturing facilities. This individual will work in a team environment, collaborating with various colleagues in the organization to solve a wide range of complex problems in creative and practical ways.
Specific Responsibilities include:
Work collaboratively within the Upstream group to execute and participate in the design of bench scale experiments
Design experiment, perform data analysis and interpret results independently
Present data and results within department and project teams
Author internal procedures and technical reports
Contribute to project teams for technology transfer to pilot scale or commercial manufacturing
Collaborate with upstream groups at France and Belgium
Set-up and maintain upstream laboratory equipment, systems, and training
BS/MS in Chemical engineering, biology, chemistry, or closely related discipline with 2-5 years’ professional industry experience.
Must have permanent US work authorization
Experience in biotechnology or pharmaceutical industry
Hands-on experience at laboratory, pilot, or manufacturing scale for biologics products
Knowledge in cell culture process development, bioreactor design and control strategies, scale up and scale down as applied to mammalian-expressed proteins
Excellent scientific background
Highly motivated individual with the ability to work independently and on cross-functional and cross-site teams
Strong technical writing and presentation skills
Experience with statistical analysis software
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.