Sanofi Group Senior Associate Scientist, Protein Analytics in Framingham, Massachusetts
We are seeking a highly motivated individual to join our dynamic and innovative team of scientists in the US Biologics Research Protein Production Group. We are dedicated to the rapid expression, purification and characterization of recombinant proteins and antibodies to advance exciting discovery research projects in Sanofi’s portfolio spanning Oncology, Immunology and Inflammation, Neuroscience and Rare Disease. The primary responsibilities for this position will focus on the application of cutting-edge analytical technologies to support the quality control and characterization of our recombinant protein and antibody production.
Requires Bachelor’s degree in Biology, Biochemistry, Analytical Chemistry or related discipline with a minimum of 4 years’ experience or master’s degree with a minimum of 1 year of relevant industry experience.
Requires hands on experience in:
Protein analysis and quality control by SEC-HPLC, SDS-PAGE, CE-SDS, and LAL endotoxin assay.
Protein binding kinetics, epitope binning, and protein quantitation using BLI (Octet) and SPR (BIAcore, Carterra LSA).
ELISA-based immunoassays and immunoblotting (western blot).
Familiarity with DLS, SLS, and SEC-MALS systems.
The candidate should have excellent communication skills, the ability to present data in well-organized written and oral formats, and to work effectively in a collaborative team environment.
Experience with intact mass analysis by LC/MS.
Protein charge variants determination by cIEF, CZE, or IEX.
Protein expression from mammalian, insect cells and/or E. coli.
Experience using automated protein purification systems such as AKTA or similar.
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