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Sanofi Group Scientist Viral Vector Manufacturing Platform Development, in Framingham, Massachusetts

Position Overview/Department Description:

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products. This organization encompasses Pre-development, Cell Culture and Purification Process Development, Analytical Development, Drug Product Development and Clinical Manufacturing. The GMU Pre-Development group operates with the mission to develop robust, scalable, and innovative viral vector manufacturing platforms to support Sanofi’s genomic medicine pipeline.

As a member of the Pre-Development team, the successful applicant will make important contributions to the optimization of the stable producer cell line platform for AAV vector manufacturing. The successful candidate will be a highly motivated scientist with broad knowledge in mammalian gene expression systems and experience in viral vector production and cell line engineering.

Key Responsibilities:

  • Conduct molecular biology and mammalian cell culture experiments to characterize and optimize AAV vector production from stable producer cell lines and HEK293 cells

  • Design and implement gene expression strategies, including inducible gene expression systems, to enhance cell line performance

  • Apply cell line engineering (via gene editing, knockout, overexpression) to improve AAV vector productivity

  • Contribute to project, technical and strategic teams as appropriate

Basic Qualifications:

  • PhD degree in Biotechnology, Cell Biology, Biochemistry, Virology or related discipline, or Masters degree with a minimum of 4 years relevant experience or a Bachelors degree with a minimum of 6 years of relevant experience

  • Strong background in molecular and cell biology, preferably in the context of virology and host/viral interactions

  • Expertise in basic molecular biology techniques (molecular cloning, qPCR, SDS-PAGE, Western blot, ELISA, etc.)

  • Demonstrated experience in mammalian gene expression systems

  • Strong cell culture expertise as demonstrated by experience with a variety of cell lines, including suspension cell lines and execution of mammalian tissue culture techniques

  • Excellent oral and written communication skills

  • Demonstrated ability to function within a collaborative/team-oriented environment

Preferred Qualifications:

  • Molecular understanding of viral vector production, in particular Adeno-Associated Virus biology, is highly desired

  • Experience in the development of stable AAV producer cell lines and/or vector production via the HEK293 transient transfection platform

  • Proficiency in use of SnapGene molecular biology software and bioinformatics tools

  • Experience with RNAseq and metabolomics analyses

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health.This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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