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Sanofi Group Scientist, In Vitro Antibody Discovery in Framingham, Massachusetts

Position Overview:

At Sanofi we are committed in our quest to be a world-class biologics research organization and are steadfast in our goal to bring next generation, transformative therapies to patients. Our global Large Molecule Research (LMR) platform consists of five sites, and approximately 550 personnel focused on antibodies, nanobodies and synthorins as therapeutic modalities. Our platform enables and partners closely with other research platforms and therapeutic areas (Immunology, Oncology, Rare Disease and Neurology) in the discovery and ultimate delivery of new candidate molecules into our pipeline.

To continue to build on our success in these efforts we are seeking an experienced, versatile, and self-driven individual to join the Antibody Discovery group at our US site. This position will directly contribute to lead discovery efforts of next generation biotherapeutics across all therapeutic areas, with strong focus on multi-specific modalities. The successful candidate will have demonstrated in-depth understanding of in vitro display methodologies (i.e., mammalian, phage or yeast), antibody discovery workflows, protein engineering, sequence analysis so as to excel in a fast-paced environment. The candidate will be responsible for advanced lab activities, including platform technology and innovation, and is expected to have an impact at the organizational level in a matrix team environment.

This is an exciting opportunity to join a group of accomplished scientists focused on the design and realization of advanced therapeutic modalities, including multi-specific molecules akin to those that have recently entered the clinic.

Key Responsibilities :

  • Design target-focused in vitro antibody discovery strategies and carry out discovery campaigns using phage- and yeast-displayed antibody libraries.

  • Execute hands-on lab work to apply molecular biology, high throughput screening, binding kinetics and epitope binning analysis, and rational antibody engineering techniques to generate therapeutic lead molecules.

  • Aid in the development and execution of microfluidic experiments to capture single immune cells in droplets for the generation of natively- paired antibody libraries.

  • Develop and/or adapt HT-amenable biochemical assays (ELISA, flow cytometry, SPR, etc.) in support of hit identification.

  • Act as a subject matter expert in antibody discovery and provide technical guidance and/or project specific feedback to pre-clinical project teams.

  • Execute several projects simultaneously and act as a point of accountability for in vitro display efforts on projects.

  • Work collaboratively with other antibody discovery teams, locally and globally.

  • Analyze and present data, both in written reports and oral presentations.

  • Effectively manage projects and resources to maximize progress.

Qualifications:

  • PhD in Biochemistry, Molecular or Structural Biology, Chemical/Biological Engineering or a closely related field with focus on antibody engineering; or MS in above field(s) plus minimum 3 years relevant research experience in an academic or biopharmaceutical setting; or BS in above field(s) plus minimum of 6 years of relevant experience.

  • Experience with in vitro display (phage, yeast, or mammalian) and HT screening is required.

  • Experience with microfluidics, NGS/deep mining, biochemical assay development, kinetic characterization and/or multi-specific modalities is highly preferred.

  • Highly analytical mind, attention to detail, and organizational skills are critical.

  • Self-starter with a strong sense of responsibility, integrity, and a collaborative spirit.

  • Ability to work independently to design and trouble-shoot experiments.

Special note : This job will be based out of Cambridge, MA starting Q2 2022

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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