Sanofi Jobs

A new perspective. A new challenge. A new opportunity.

Job Information

Sanofi Group Scientist, GMU CMC Vectorology in Framingham, Massachusetts

Position Overview:

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best in class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. This organization encompasses vector and cell line engineering, upstream and downstream process development, analytics, and clinical manufacturing support.  

The Vectorology group is responsible for the design, construction and QC of plasmids used for commercial production of recombinant AAV, as well as providing vectorology support to other efforts within the unit. We seek a highly motivated scientist with hands-on experiences in molecular cloning, mammalian tissue culture and knowledge in AAV biology or virology to join the team.

Key Responsibilities:

  • Independently design and construct viral vector and gene expression plasmids with minimal supervision.

  • Produce and QC plasmids to meet sequence, purity and bioburden requirements.

  • Perform mammalian tissue culture experiments (transfections, infections) to verify plasmid functionality.

  • Develop, maintain and demonstrate advanced knowledge of principles and techniques in molecular cloning, cell culture, AAV biology and viral vector production.

  • Communicate effectively with internal teams and external CROs.

  • Deliver plasmids on pipeline programs within aggressive timelines.

  • Keep up to date on industry knowledge and advancements; provide input on optimization of process or capability.

  • Write notebooks and protocols; author reports to support regulatory filings; present findings/results in multi-functional team meetings.

  • Mentor and support junior staff and build a culture of support and collaboration.

  • Provide a functional and safe working environment while maximizing laboratory efficiency.

Basic Qualifications:

  • PhD in virology or related biological sciences, Master’s degree with a minimum of 4 years of relevant industry experience or a Bachelor’s degree with a minimum of 6 years of relevant industry experience.

  • Strong expertise in molecular cloning of vector plasmids (restriction digestion, ligation and screening), experience with AAV ITR plasmids a plus.

  • Expertise in basic molecular biology techniques (qPCR, SDS-PAGE, westerns, ELISAs, etc.).

  • Skilled with primer design, Sanger sequencing and sequence analysis software.

  • Experience with next generation sequencing (Illumina or PacBio platform) and NGS related data analysis preferred.

  • Good knowledge of principles and techniques in AAV biology and molecular virology.

  • Hands-on experience with mammalian tissue culture (adherent and suspension cells) and viral vector production.

  • Ability to design complex cloning strategy independently with minimal guidance.

  • Ability to interpret results analytically and troubleshoot technical problems.

  • Excellent communication and presentation skills.

  • Excellent organization and attention to detail; critical and creative thinker.

  • Able to work in a collaborative / team-oriented environment and commit to internal documentation practices.

  • Ability to work in Biosafety Level 2, follow safe lab procedures and maintain good laboratory practice (GLP).

Preferred Qualifications:

  • Experience with inducible gene expression systems.

  • Knowledge of multiple viral vector expression platforms and industrial process development.

  • Working knowledge of other molecular cloning methods, such as Gibson assembly, Golden Gate assembly or Ligation Independent Cloning method.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.