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Sanofi Group Scientist, Biologics Characterization-Mass Spectrometry in Framingham, Massachusetts

Description

This scientist position resides within the Bioanalytics Characterization group which is a part of the Biologics Development organization. The successful candidate will utilize advanced bioanalytical tools with a focus on mass spectrometry and chromatography based techniques to characterize a variety of biotherapeutics at all stages of development to enable critical decision-making and ensure the successful development of new drugs.

Responsibilities

  • Identify sequence liabilities in therapeutic proteins to assist pre-candidate selection in developability assessment.

  • Perform detailed structural characterization including protein sequence confirmation, sequence variant identification, qualitative and quantitative analysis of post-translational modifications (e.g. glycosylation and disulfide bonds) in support of batch release, IND enabling studies, forced degradation and comparability studies.

  • Collaborate with group members and cross functional teams to support structure-function studies, process development, and formulation studies.

  • Evaluate and develop new technologies to improve the quality and efficiency of the characterization workflows and to solve problems encountered during drug development.

  • Author technical reports, study protocols and manuscripts for publication; present at internal and external seminars and conferences.

Basic Qualifications:

  • PhD in Biochemistry or a relevant discipline, or a Master's degree with a minimum of 4 years of experience, or a Bachelor's degree and at least 6 years of experience

  • Expertise in protein mass spectrometry including LC-MS intact protein analysis, peptide mapping, and PTM characterization.

  • Highly motivated, organized, detail-oriented and able to work in a fast-paced team environment

  • Strong problem-solving and communication skills

Preferred Qualifications:

  • Experience in glycoprotein and antibody characterization

  • Experience with analytical separation methods, biophysical characterization techniques, and high throughput automation platforms

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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