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Sanofi Group Scientist, Bioanalytics in Framingham, Massachusetts

Position Overview:

The Bioanalytics Characterization group, part of the Global CMC Development organization located in Framingham, Massachusetts, is seeking a scientist to join the team. The successful candidate will utilize advanced bioanalytical tools with a focus on mass spectrometry and chromatography-based techniques to characterize a variety of biotherapeutics at all stages of development to enable critical decision-making and ensure the successful development of new drugs.

Key Responsibilities:

  • Perform detailed structural characterization including protein sequence confirmation, sequence variant identification, qualitative and quantitative analysis of post-translational modifications (e.g. glycosylation and disulfide bonds) using state of the art mass spectrometry in support of batch release, IND enabling studies, forced degradation and comparability studies.

  • Identify sequence liabilities in therapeutic proteins to assist pre-candidate selection in developability assessment.

  • Collaborate with group members and cross-functional teams to support structure-function studies, cell line development, process development, and formulation studies.

  • Evaluate and develop new technologies to streamline and improve the efficiency of the characterization workflows and to solve problems encountered during drug development.

  • Author technical reports, study protocols and manuscripts for publication; present at internal and external meetings and conferences.

  • Operate and maintain mass spectrometry instruments.

Basic Qualifications:

  • PhD in Analytical Chemistry, Biochemistry or a related discipline, or a master’s degree with a minimum of 4 years of industry experience, or a bachelor’s degree with a minimum of 6 years of industry experience.

  • Strong track record of independent and in-depth mass spectrometry characterization of proteins including LC-MS intact protein analysis, peptide mapping, and PTM characterization.

  • Highly motivated, organized, detail-oriented and able to work in a fast-paced environment.

  • Ability to work well both independently and in a team environment.

  • Strong problem-solving, communication and inter-personal skills.

Preferred Qualifications:

  • Experience in monoclonal antibody (mAb) characterization.

  • Experience with protein separation techniques, such as chromatographic separations using RP, SEC and CEX modes, capillary electrophoretic techniques (CE and cIEF etc).

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



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