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Sanofi Group Principal Scientist in Framingham, Massachusetts

Position Overview:

At Sanofi we are committed in our quest to be a world-class biologics research organization and are steadfast in our goal to bring next generation, transformative therapies to patients. Our global Large Molecule Research (LMR) platform consists of five sites, and approximately 550 personnel focused on antibodies, nanobodies and synthorins as therapeutic modalities. Our platform enables and partners closely with other research platforms and Sanofi’s therapeutic areas (Immunology & Inflammation, Immuno-Oncology, Rare & Neurologic Diseases) in the discovery and ultimate delivery of new candidate molecules.

Our Protein Engineering group within the Large Molecule Research Platform US is seeking a highly motivated and talented biophysical scientist with strong expertise in protein structure-function relationship, protein-protein interactions, protein biochemical and biophysical characterization, and HTP assay development. Our Protein Engineering group has a great track record of patents and publications in Fc engineering and multi-specific antibodies (incl. Science, Nature), and has developed novel mode of actions with structure-based design. The successful candidate will work in a collaborative environment to develop and implement assays for enabling candidate selection within Sanofi’s promising pipeline of biotherapeutics. This is an exciting and unique opportunity to contribute to resolving challenges in early prediction of developability characteristics in large molecule drug R&D and make impacts to patients’ lives.

Key Responsibilities:

  • Plan and execute developability assessments in accordance with Sanofi standards.

  • Collaborate with colleagues from Discovery, Production, Analytics, Engineering and Development to continuously evolve methods for early developability risk assessment.

  • Implement HTP methods for biochemical and biophysical characterization of highly engineered therapeutic antibodies.

  • Analyze large data sets to identify trends and correlation between biophysical characteristics and drug like properties.

  • Evaluate and establish leading edge methods to expand HTP analytics capabilities in the Large Molecule Research group.

  • Closely monitor leading edge developments in scientific literatures and develop new skills in the area of therapeutic candidate credentialing technologies, and characterization of protein solution properties.

Basic Qualifications:

  • PhD in Biochemistry or a related discipline with 5+ years of relevant industry experience in characterizing protein therapeutics.

  • Hands-on experience and deep understanding of protein structure, chemistry, and degradation mechanisms and biophysical/analytical characterization methods, such as thermal stability analysis, charge variant analysis, solution behavior, light scattering and standard chromatography techniques.

  • Proficient with protein-protein interaction technologies, such as Surface Plasmon Resonance (SPR) or Bio-Layer Interferometry (BLI) methods and instruments.

  • Experience in automating highly complex analytical methods for sample management/ handling and data analysis/ curating/ interpretation.

  • Experience working on developability of multi-specific antibodies is strongly preferred.

  • Strong drive for self-development with a focus on scientific know-how.

  • Excellent problem solving and written/oral communication skills, as well as scientific writing, presentation, and collaboration skills.

  • Track record of scientific accomplishments as evidenced by a strong publication record.

  • Strong work ethic, team-oriented, project-focused, and motivated to produce high quality data on an aggressive timeline.

  • Strong leadership qualities with an established track record of success and be motivated to work cross-functionally to bring people together.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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