Sanofi Group Principal Research Associate in Framingham, Massachusetts
We are seeking a highly motivated and talented Principal Research Associate to join our Developability & Preformulation Sciences (DPFS) group. DPFS is part of the global Biologics Drug Product Development organization, a critical R&D function enabling the manufacturing of stable and deliverable dosage forms along the complete development timeline from molecule selection to commercial tech transfer.
Part of a team with global responsibility for enabling candidate selection within Sanofi’s promising pipeline of biotherapeutics, for determining the formulation space for a variety of biotherapeutic modalities, and for charting the roadmap to continuously improving capabilities in the prediction, characterization, and control of the molecular liabilities that limit the development of stable and manufacturable drugs
Timely execution of laboratory studies in support of developability assessments and preformulation workflows
Support research activities focused in the areas of therapeutic candidate credentialing technologies, characterization of protein solution properties, the molecular basis of high concentration behaviors, and early-stage prediction of in vivo biologic performance metrics.
Bachelor’s degree in Biochemistry or a related discipline with a minimum of four years of relevant laboratory experience or a master’s degree with a minimum of two years of relevant laboratory experience.
Self-motivated with experience working on project team
Solid understanding of protein structure, chemistry, and degradation mechanisms is required.
Excellent communication and presentation skills and
Working knowledge of the fundamental biopharmaceutical principles of developing injectable biologic drug products
Practical experience with biochemical and biophysical characterization methods such as chromatography, electrophoresis, UV/CD/fluorescence spectroscopies, calorimetry, light scattering, and sedimentation
Experience with mammalian cell culture and protein expression, particularly as it pertains to expression of biopharmaceuticals in suspension culture
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.