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Sanofi Group Principal Research Associate in Framingham, Massachusetts

Position/Department Overview:

We are seeking a highly motivated and talented Principal Research Associate to join our Developability & Preformulation Sciences (DPFS) group. DPFS is part of the global Biologics Drug Product Development organization, a critical R&D function enabling the manufacturing of stable and deliverable dosage forms along the complete development timeline from molecule selection to commercial tech transfer.

Key Responsibilities:

  • Part of a team with global responsibility for enabling candidate selection within Sanofi’s promising pipeline of biotherapeutics, for determining the formulation space for a variety of biotherapeutic modalities, and for charting the roadmap to continuously improving capabilities in the prediction, characterization, and control of the molecular liabilities that limit the development of stable and manufacturable drugs

  • Timely execution of laboratory studies in support of developability assessments and preformulation workflows

  • Support research activities focused in the areas of therapeutic candidate credentialing technologies, characterization of protein solution properties, the molecular basis of high concentration behaviors, and early-stage prediction of in vivo biologic performance metrics.

Basic Qualifications:

  • Bachelor’s degree in Biochemistry or a related discipline with a minimum of four years of relevant laboratory experience or a master’s degree with a minimum of two years of relevant laboratory experience.

  • Self-motivated with experience working on project team

  • Solid understanding of protein structure, chemistry, and degradation mechanisms is required.

Preferred Qualifications:

  • Excellent communication and presentation skills and

  • Working knowledge of the fundamental biopharmaceutical principles of developing injectable biologic drug products

  • Practical experience with biochemical and biophysical characterization methods such as chromatography, electrophoresis, UV/CD/fluorescence spectroscopies, calorimetry, light scattering, and sedimentation

  • Experience with mammalian cell culture and protein expression, particularly as it pertains to expression of biopharmaceuticals in suspension culture

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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