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Sanofi Group Lab Head, Protein Engineering, Senior Principal Scientist in Framingham, Massachusetts

We are seeking a passionate and highly experienced Protein Designer to join our Protein Engineering group within Sanofi US Biologics Research Department . Protein Engineering group has a great track record of patent and publication in the areas of Fc engineering and multispecific antibodies. We have a state-of-art structure biology capability within the group, offering a unique opportunity to collaborate closely on Protein Engineering projects. This Lab Head (Senior Principal Scientist) position will lead a small team of scientists to work closely within a dynamic, fast-paced and highly collaborative environment of Protein Engineering group. The successful candidate should be an expert in creatively applying structure-guided design principles to diverse therapeutic biologics modalities to engineer molecular formats or attributes, such as affinity, activity or developability. Previous experience in designing multispecific/multivalent antibody formats and Fc-engineered fusion molecules in the Oncology, Immuno-Oncology or Immunology & Inflammation therapeutic area is required. S/he must have deep understanding of protein science to provide technical insights and strategies to characterize and interpret biochemical, biophysical and functional attributes of engineered biologics. In addition, s/he will represent Biologics Research Department in cross-functional project teams to identify opportunities in discovery biology enabled by protein engineering and provide the strategy. Previous experience in project and people management is required. Strong interest or experience in other areas of protein engineering, such as glycoengineering and chemical conjugation, or in the area of computational biology , such as in silico structure modeling and analysis, machine learning and de novo design, will be highly preferred.

RESPONSIBILITIES

  • Develop and engineer bi-specific and multi-specific antibody-based therapeutics and fusion proteins through structure-based design, with the focus on Oncology, Immuno-oncology and Immunology & Inflammation

  • Provide technical strategy and insights to screen and analyze the engineered biotherapeutics for improved biological properties, biochemical and biophysical characteristics

  • Actively interact with Therapeutic Area project teams to identify and provide a protein engineering strategy and lead the effort

  • Represent Biologics Research (BR) Department in cross-functional project teams, coordinate/lead the BR activities, and work closely together with the Therapeutic Area Project Lead for milestone transitions

  • Manage and develop a team of 2-3 junior scientists and supervise their projects

  • Document and present experimental results, conclusions and interpretations at departmental and cross-functional project team meetings

  • Write scientific publications and present at conferences. Contribute to patent applications.

QUALIFICATIONS

  • Ph.D degree in Biochemistry/ Molecular Biology/ Structural Biology or a related discipline with 7+ years of industry experience in Biotech/Pharmaceutical environment AND prior experience in project and people management

  • Self-motivated and highly collaborative to work in a cross-cultural, multidisciplinary, team-oriented environment with excellent oral and written communication skills and organization skills

  • Strong desire to identify and drive technical innovation in protein engineering

  • Proven expertise in antibody/protein design projects in the area of Immuno-Oncology or Immunology & Inflammation, especially multispecific or multivatlent antibody format engineering, Fc-fusions and Fc engineering

  • Well-versed in structure biology, protein engineering technologies and principles, including molecular biology, mutagenesis methods, antibody/protein structure-function relationships, biophysical/biochemical analysis

  • Experienced in a wide range of screening assays and (high-throughput) analytical and biophysical methods, such as ELISA, ALPHAScreen, Octet, Biacore, MSD, Carterra,iQue Screener, HPLC/UPLC, DSC/DSF, MALS ;

  • Experienced in protein expression in mammalian and bacterial expression system, yeast/phage display library, protein purification, flow cytometry and cell-based and/or immune assays

  • Track record of scientific accomplishments as evidenced by a strong publication record

  • Experience with mass spectrometry a plus

  • Strong interest or experience in other areas of protein engineering, such as glycoengineering and chemical conjugation, or in the area of computational biology , such as in silico structure modeling and analysis, machine learning and de novo design, will be highly preferred

  • Protein modeling and in silico analysis using PyMOL, Rosetta, MOE, Discovery Studio or a similar tool a plus

  • Familiarity with antibody discovery techniques and workflow preferred

EEOC Statement

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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