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Sanofi Group Bioanalytics Characterization Scientist in Framingham, Massachusetts

Position Overview:

The Bioanalytics Characterization group, part of the Global CMC Development organization located in Framingham, Massachusetts, is seeking a scientist to join the team. The successful candidate will utilize advanced bioanalytical tools with a focus on characterizing the structure-function relationship of a variety of biotherapeutics at all stages of development to enable critical decision-making and ensure the successful development of new drugs.

Key Responsibilities:

  • Protein purification using column chromatography (operation of manual and automated chromatography systems, i.e. AKTA and HPLC).

  • Perform analytical assays including protein quantification, cIEF, CE, SPR, IEX, HIC, SEC, etc.

  • Complete detailed structural characterization including sequence variant identification, qualitative and quantitative analysis of post-translational modifications (e.g. glycosylation and deamidation) using state of the art mass spectrometry.

  • Mammalian tissue culture for protein expression and cell based assays.

  • Collaborate with group members and cross-functional teams.

  • Evaluate and develop new technologies to streamline and improve the efficiency of the characterization workflows and to solve problems encountered during drug development.

  • Author technical reports, study protocols and manuscripts for publication; present at internal and external meetings and conferences.

Basic Qualifications:

  • PhD in Biochemistry, Life Sciences, or a related discipline or a master’s degree with a minimum of 4 years of industry experience or a bachelor’s degree with a minimum of 6 years of industry experience.

  • Strong track record of independent and in-depth protein purification and analysis

  • Proven experience with mass spectrometry characterization of proteins including LC-MS intact protein analysis, peptide mapping, and PTM characterization.

  • Highly motivated, organized, detail-oriented and able to work in a fast-paced environment.

  • Ability to work well both independently and in a team environment.

  • Strong problem-solving, communication and inter-personal skills.

Preferred Qualifications:

  • Experience with mammalian tissue culture and cell assays.

  • Experience with SPR.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.




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