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Sanofi Group Sr. Principal Scientist, Immuno-Oncology Bioinformatics in Cambridge, Massachusetts

We seek an experienced computational biologist / data scientist to identify and advance new immuno-oncology therapies for solid tumors and hematological malignancies.

In this hands-on role, you will work as an integral part of project teams to identify targets, advance programs, and develop and test actionable biomarker strategies for programs in Oncology, with emphasis on our Immuno-Oncology therapeutic area. You will use patient genomic data from internal studies, collaborations, and the literature to identify mechanisms and targets for overcoming immunosuppression. You will design, interpret, and analyze high-content experiments such as bulk and single cell NGS and multiplexed flow cytometry to identify relevant mechanisms and targets and characterize drug mechanism of action. You will be responsible for presenting your work internally in project teams and larger-scale forums and externally in scientific publications and presentations.

Summary of Key Responsibilities:

Develop and execute computational strategies for disease characterization from back-translational studies both to identify and to rank actionable targets / combinations

Develop actionable biomarker plans (e.g., selection, PD, efficacy biomarkers) in collaboration with project teams

Proactively engage with project teams to define crisp scientific questions that can be addressed with appropriately powered experimental designs

Apply scientific expertise and judgement to initiate, design, direct and analyze experiments and/or studies in support of research and/or development projects.

Education and experience

Educational requirements:

Ph.D. in a computational, statistical, biophysics, or bioinformatics related fields with emphasis on biological data analysis

Professional experience:

A minimum of 8+ years pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology or a related field

Specific skills and competencies

An ideal candidate will be collaborative, self-directed and possess:

First-hand experience in using patient and preclinical NGS data to develop and support target selection or biomarker strategies.

Demonstrated expertise in Oncology or Immune-Oncology

Demonstrated contributions to multi-disciplinary collaborations

Proficiency in bioinformatic analysis using R or Python

Familiarity with standard methods for bioinformatic data analysis and reference datasets

Strong written and verbal communication skills

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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