Sanofi Group Senior Associate Scientist – Immunology in Cambridge, Massachusetts
The Autoimmunity & Type 1 Diabetes Cluster, within the Immunology & Inflammation Therapeutic Area (TA), aims to discover new mechanistic pathways in autoimmune diseases and develop these findings into novel disease-modifying drugs that improve the lives of patients. Our focus is on inflammatory diseases driven by self-reactivity and characterized by loss of immunological tolerance. The current major emphasis is on systemic lupus erythematosus and type 1 diabetes, but may extend into other immune-mediated areas (such as multiple sclerosis, rheumatological and antibody-mediated diseases) when our science and discoveries lead us.
We wish to recruit a Senior Associate Scientist who will work in a dynamic, matrix laboratory team environment, with the aim of identifying new disease targets and taking these through to drug development. Our target discovery process is facilitated by extensive collaboration across our other TA Clusters (focused on Checkpoint Immunity, Type 2 Inflammation & Fibrosis, Type 1 and Type 17 Immunity, and Precision Immunology) as well as with our platforms in drug discovery, biologic molecules, and disease model pharmacology.
The successful candidate should have a solid background in immunology and demonstrated ability to integrate into projects/assignments as part of a dynamic team, contributing technical skills and functional knowledge. Evidence of technical expertise in APC and T/B-cell biology, immune regulation, immune tolerance, and cytokine biology is highly desirable, as well as experience developing novel immunoassays and finding solutions to technical or research questions. S/he should be able to work with a high degree of flexibility and under limited supervision, managing time efficiently to enable contribution to multiple projects simultaneously. The candidate will join a Cluster that is committed to finding solutions to autoimmune diseases and comprises three other laboratory teams, each with senior scientific leadership and similar goals.
Participate in programs through design and execution of laboratory experiments to identify novel targets and develop therapeutic molecules to modulate pathways for autoimmune disease intervention.
Coordinate studies with group members as well as with our colleagues in other TA Clusters and platforms such as in vivo pharmacology.
Oral and written communication of projects and data packages to varied audiences.
Maintain awareness of current scientific developments in our field and integrate this knowledge into our activities.
Mentor scientists in the Cluster and be accountable for effective performance of the team and its individuals.
Ensure productive and efficient utilization of department resources to meet project timelines.
Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling and disposal of materials such as controlled drug substances, biohazardous material, and radioactive compounds.
Basic qualifications and requirements include:
Bachelor’s Degree plus a minimum of 4 years OR Master’s Degree plus a minimum of 1 year of relevant research experience in an academic or biopharmaceutical setting; hands-on industry experience designing, executing, and documenting cell-based pharmacology experiments is preferred but not required.
Demonstrated background in cellular immunology is essential: experience isolating primary mouse and human immune cell subsets for utilization in immunological assays would be highly desirable as would working knowledge of multi-color flow cytometry and FACS-based immunophenotyping; in vivo mouse experience (live handling, post-mortem tissue acquisition), or the willingness to learn, would be highly desirable but not required.
Proficiency across cellular, biochemical, and molecular techniques, which may include: stable cell line generation and characterization, protein detection (ELISA, MSD, Luminex), and gene profiling (RT-PCR, NanoString, NGS).
S/he must be scientifically rigorous, highly organized, and self-motivated; must be able to work independently while interacting and maintaining strong working relationships with a diverse group of research collaborators.
Demonstrated curiosity and ability to master new scientific disciplines, troubleshoot both technical and scientific problems, and analyze and interpret experimental data and suggest next steps.
Ability to effectively present and communicate complex data sets to diverse audiences.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.