Sanofi Group Scientist - Immunology in Cambridge, Massachusetts
The Autoimmunity & Type 1 Diabetes (T1D) Cluster, within the Immunology & Inflammation Therapeutic Area (TA), aims to discover new mechanistic pathways in autoimmune diseases and to develop these findings into novel disease-modifying drugs that improve the lives of patients. Our focus is on inflammatory diseases driven by self-reactivity and characterized by loss of immunological tolerance. The major emphasis is on disease pathways that are characterized by uncontrolled immune activation, both innate and adaptive, and mechanisms of immune regulation. Disease areas of interest reflect these biologies and include systemic lupus erythematosus (SLE), inflammatory bowel disease and T1D and may extend into other immune-mediated disease areas according to where our science and discoveries lead us.
We wish to recruit a Scientist who will work in a dynamic, matrix laboratory team environment, with the aim of identifying new disease targets and taking these through to drug development. Our target discovery process is facilitated by extensive collaboration across our other TA Clusters (focused on Checkpoint Immunity, Type 2 Inflammation & Fibrosis, Type 1 and Type 17 Immunity, and Precision Immunology) as well as with our platforms in drug discovery, biologic molecules, and disease model pharmacology.
The successful candidate should have deep knowledge of immunology and demonstrated ability to integrate into projects and assignments as part of a dynamic team, contributing technical skills and functional knowledge. Evidence of technical expertise in APC and T/B-cell biology, immune regulation, immune tolerance, and cytokine biology is expected, as well as experience developing novel immunoassays and hypotheses and finding solutions to technical or research questions. S/he should be able to work with a high degree of flexibility and under limited supervision, managing time efficiently to enable contribution to multiple projects simultaneously. The candidate will join a Cluster that is committed to developing novel autoimmune disease therapies and is comprised of three other laboratory teams, each with senior scientific leadership and similar goals.
Propose, participate in and/or lead discovery programs through design and execution of laboratory experiments to identify novel targets and develop therapeutic molecules to modulate pathways for autoimmune disease intervention.
Coordinate studies with group members as well as with our colleagues in other TA Clusters and platforms such as in vivo pharmacology.
Oral and written communication of project updates and data packages to varied audiences.
Maintain awareness of current scientific developments in the autoimmunity field and integrate this knowledge to improve and enhance current research activities.
Ensure productive and efficient utilization of department resources to meet project timelines.
Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling and disposal of materials such as controlled drug substances, biohazardous material, and radioactive compounds.
Build and maintain collaborative relationships within a work matrix that includes partners in Translational Sciences, Clinical Development, Drug Metabolism & Pharmacokinetics, and Biologics to build a shared work plan and ensure alignment between stakeholders.
This position requires significant hands-on laboratory bench and has no direct reports; however, s/he may have the opportunity to mentor scientists in the Cluster and will be accountable for effective performance of team members.
Ph.D. in immunology or related field with at least 1 year of post-doctoral laboratory experience OR Master’s degree plus >3 years laboratory experience in an academic or biopharmaceutical setting.
Demonstrated expertise in immunology, particularly related to autoimmunity and mechanisms of immune tolerance.
Significant experience isolating primary mouse and human immune cell subsets for utilization in immunological assays; advanced knowledge of high-dimensional flow cytometry and FACS-based immunophenotyping (both panel design and downstream data analysis using FlowJo, Cytobank, or similar software).
Proficiency across cellular, biochemical, and molecular techniques, which may include stable (reporter) cell line generation and characterization, protein detection (MSD, Luminex), and gene profiling (RT-PCR, NanoString, NGS).
The following would be highly desirable but are not a prerequisite: working knowledge and experience relevant to discovery and development of small and large molecules; in vivo mouse experience (live handling, post-mortem tissue acquisition and processing), or the willingness to learn; experience working with large transcriptome datasets to identify novel targets and pathways (bulk- or single-cell RNAseq) for subsequent validation (CRISPR/Cas9 gene editing).
S/he must be scientifically rigorous, highly organized, and self-motivated; must be able to work independently while interacting and maintaining strong working relationships with a diverse group of research collaborators.
Demonstrated curiosity and ability to master new scientific disciplines, troubleshoot both technical and scientific problems, and analyze and interpret experimental data and suggest next steps.
Ability to effectively present and communicate complex data sets to diverse audiences.
Excellent organizational and project management skills required.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.