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Sanofi Group RNA Machine Learning Senior Scientist, Vaccines in Cambridge, Massachusetts

Position Overview:

In the race for the future of health – The Sanofi mRNA Center of Excellence

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join the team at our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 400 dedicated employees for it and using it as the foundation to implement integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism for the future to Sanofi. Join us.

Sanofi Pasteur, Vaccine R&D is strategically developing and deploying state-of-the-art digital strategies/tools to meet Sanofi Pasteur's mission to become the disruptive market leader in vaccines. Vaccine R&D seeks entrepreneurial and forward-thinking individuals to drive the development of Artificial Intelligence (AI) / Machine Learning (ML) / Deep Learning (DL) solutions to improve efficiency and effectiveness across research and development.

S/he will have deep knowledge and experience in both RNA Biology/Biophysics/Biochemistry and bioinformatics/data science/machine learning and the ability to rapidly transform theory to actionable prototype. S/he will be responsible for designing, prototyping and validating computational solutions to diverse scientific challenges in the fields of mRNA vaccines and therapeutics. S/he will have a high degree of proficiency in Python/R, machine learning and deep learning libraries, bioinformatics tools and cloud computing.

S/he will be ready to hit the ground running in a fast-paced environment that rewards personal initiative, collaboration, and scientific excellence.

Key Responsibilities:

  • Collaborates with stakeholders and other group experts in the development and execution of the scientific strategy and technical solutions to develop best-in-class mRNA vaccines and therapeutics

  • Acts as a scientific expert and partner in the fields of RNA biology/biochemistry/biophysics and AI/ML

  • Lead efforts to design and optimize mRNA vaccines, optimize formulations, predict performance

  • Design and assess studies to evaluate the performance of mRNA vaccines and therapeutics. Translate experimental learnings into the development and refinement of computational models for design, optimization, selection and formulation of mRNA vaccines

  • Develops and evaluates computational and statistical methods for data analysis

  • Develops, deploys, and assesses the results of at-scale models at varying levels of model granularity encompassing heterogeneous preclinical and clinical data

  • Employs machine learning methods such as deep learning, neural networks, reinforcement learning, graphical and generative models to deconvolve high dimensional experimental and in silico modeling results

  • Maintains a well-documented, reusable codebase, and traceable model history

  • Generates IP and participates in the drafting of patent filings

Basic Qualifications:

  • Advanced degree in computational biology/molecular biology (RNA) with expertise in machine learning or an advanced degree in computational sciences, machine learning or other technical fields with expertise in RNA biology

  • Deep knowledge and experience in RNA biology/biophysics/biochemistry (structure, function, engineering)

  • High proficiency in machine learning (Deep Learning, Embeddings, Reinforcement and Transfer Learning) and algorithmic analysis of data

  • Demonstrated record of transforming algorithms/theory into practical applications delivering robust models that are high performance, interpretable and actionable.

  • A creative problem solver, skilled in divergent thinking and turning complex data into actionable insights and knowledge

  • Excellent communication, scientific writing and presentation skills. Ability to develop and present results as visually appealing and understandable stories

  • Understanding of drug/vaccine discovery and development processes is a plus

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#mRNA

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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