Position Title

Senior Principal Scientist, Investigative Toxicology

Job overview

Sanofi is seeking an innovative investigative toxicologist to join our Preclinical Safety organization in a position that offers exciting and challenging scientific opportunities in a global environment. The incumbent will be responsible for contributing to the remit of the Global Investigative Toxicology organization at Sanofi, helping to resolve safety issues, develop scientific models and assays for safety assessment, investigate mechanisms of toxicity, and provide subject matter expertise as needed. They will provide scientific input, including analysis and interpretation of data, to aid understanding and characterization of toxicologic liabilities and aid in the development of novel therapeutics with reduced safety risk. The successful candidate will possess the ability to delve into toxicity findings, propose scientific hypotheses, and design and execute investigative plans to understand potential underlying mechanisms. Critical thinking is a key attribute, as is the ability to synthesize and interpret data, and understand and convey key messages. The successful candidate will bring a valuable, diverse skillset to Sanofi, and work transversally with colleagues across the company to promote the interests of patient health and safety.


  • Propose and conduct investigative strategies to understand mechanisms of toxicity. Clearly communicate strategies, execution plan and subsequent study findings to project teams and Preclinical Safety management as necessary and provide advice on the early research program or clinical and regulatory strategy as required.

  • Oversee projects within Investigative Toxicology, including providing matrix management of laboratory colleagues and facilitating use of appropriate internal and external resources as needed.

  • Guide and oversee assessment of new and innovative tools and models and their application to Toxicology and the Sanofi portfolio.

  • Analyze and interpret data from experiments conducted by laboratory colleagues, provide direction on subsequent experimental plans, and author investigative reports on the results for inclusion in white papers or regulatory submissions as needed.

  • Work collaboratively and transversally to assist project team members in understanding toxicologic and pharmacologic relevance and implication of in vivo and in vitro study findings as necessary and assist in addressing queries from regulatory agencies.

  • Participate in relevant external consortia or working groups to stay abreast of evolving knowledge and trends within the scientific community and the pharmaceutical industry. Represent Sanofi interests, maintaining high ethical and scientific standards.

  • Author external presentations and manuscripts to contribute to the advancement of scientific knowledge.

Requirements & Qualifications

A PhD in toxicology, pharmacology, biology, or equivalent scientific discipline is required, with a minimum of 8-10 years of relevant research experience in a pharmaceutical or biopharmaceutical setting. Knowledge and experience in Investigative Toxicology is required. Direct experience analyzing RNA sequencing and other types of genomic data sets is strongly desired. Experience working with advanced in vitro systems is a plus. Knowledge of immunology or liver biology is also a plus. Established record of scientific contribution in peer-reviewed journals and scientific symposiums, and excellent verbal and written communication skills are required.

Terms of employment

Occasional domestic and international travel to Sanofi Research and Development sites (e.g - Paris, France; Frankfurt, Germany) and scientific conferences. Availability to start in 2Q2024.

What makes this position unique?

The candidate will be part of a dynamic and innovative Global Investigative Toxicology group at Sanofi and have opportunity to work on challenging scientific toxicological issues for drug candidates at all stages in the portfolio. There is tremendous opportunity for innovation within the role, and the global scope will provide the candidate with a rich, diverse work experience.

Benefits of working in this role

The candidate will:

  • Be part of an active, innovative scientific group

  • Have diverse opportunities to collaborate globally.

  • Be highly recognized for successes.

  • Receive excellent benefits and compensation.

Sanofi US endeavors to make our career center accessible to any and all users. If you are experiencing difficulty and need assistance applying online, please call 1-866-SANOFI2 (1-866-726-6342) or click here (https://www.sanofi.us/en/dam/jcr:4cdddb5f-8089-4ad8-9717-cbf1a92aa03d/RA_Career_Site.pdf) .

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

Location information

The position is based in Cambridge, MA and offers flexible working arrangements.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.