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Sanofi Group Principal Scientist, Precision Immunology in Cambridge, Massachusetts

Position Overview:

The Immunology and Inflammation Research and Early Development Therapeutic Area in Sanofi is building a world-class immunology team and is seeking a highly motivated computational scientist to lead in silico analytical projects for patients stratification and novel target identification in the fields of Type 2 Immunity and Fibrosis, Immune Checkpoint Biology, Type 1 Diabetes, Autoimmunity and Complement System.

We are seeking a Principal/Senior Principal Data Scientist to join our Precision Immunology Cluster , part of Immunology & Inflammation Research Therapeutic Area . The successful candidate will have extensive hands-on and team supervision experience for the development and application of machine learning, statistical and computational methods to solve biological problems, excellent oral and written communication skills, and the ability to learn and acquire new techniques and methodologies. The candidate is expected to lead a data analysis team aimed at the development analytical strategies and data integration platforms for the identification of novel therapeutic targets, the discovery of predictive biomarkers to aid patient stratification and clinical development plans.

This exciting role will afford scientists the opportunity to be intimately involved in early discovery research and pre-clinical development.

Key Responsibilities:

  • Lead a small team and projects to Identify candidate therapeutic targets and biomarkers for immunology, through integrated analysis of high-throughput molecular data and clinical phenotypes.

  • Develop innovative and creative computational approaches to understand complex immune conditions using multi-dimensional –omics and clinical data.

  • Work in close collaboration with data science and IT functions to develop innovative software platforms for data integration and target analysis.

  • Collaborate with experimental and systems/computational immunologists.

  • Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards.

Basic Qualifications:

  • PhD in computational biology, computer science, statistics, or a related quantitative science field with 8+ years of project-based work in computational application in biology related fields.

  • Proficiency in analyzing clinical, biological and molecular data with R, Matlab or Python.

  • Proficiency in software development and relational databases.

  • Advanced knowledge of Linux/HPC and shell scripting.

  • Proficiency in biostatistics, linear/non-linear regression models, dimensionality reduction, clustering, machine learning approaches including SVMs, and Random Forest.

  • Strong foundations on bioinformatics, genetics/genomics sciences.

  • Strong interest in biology and immunological diseases, liaise with scientists from Immunology and Inflammation to help define and address biological questions with computational and analytical approaches.

Preferred Qualifications:

  • Ability to develop, benchmark and apply predictive algorithms to identify novel biomarkers, dissect relationships and generate hypotheses.

  • Experience with Bayesian analysis and causal inference.

  • Excellent written and oral communication skills.

  • Excellent interpersonal and team skills.

Sanofi US Services, Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



Sanofi, a global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients’ needs. Sanofi has core strengths in diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and Genzyme.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.