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Sanofi Group Principal Scientist, Oncology Bioinformatics in Cambridge, Massachusetts

We seek an experienced computational biologist / data scientist with expertise in cancer genomic data analysis. This role will work with our Molecular Oncology group to identify targets and advance programs that block drivers of tumor growth, drug resistance and immune invasion. You will use large scale patient genomic datasets to identify targets in tumors with high unmet medical need, identify indications and likely patient subsets for drug candidates, and develop and implement biomarker strategies to select patients and assess drug action.

Summary of Key Responsibilities:

  • Integrate multiple data sources including patient mutation and transcriptome profiling, functional genomic screening results, and proteomic datasets to identify new cancer targets for defined patient populations

  • Collaborate with laboratory and in vivo scientists to design, analyze and interpret experiments to validate targets, understand compound mechanism of action, and identify biomarkers for patient selection and target engagement

  • Collaborate with clinical programs to implement biomarker hypotheses and perform back-translation analyses in Sanofi clinical trials

  • Participate in consortium projects for cancer patient profiling and target identifications such as Immucan and OpenTargets

Education and experience:

Educational requirements

  • Ph.D. in computational, statistical, biophysics, bioinformatics, or a related field with emphasis on biological data analysis

Professional experience:

  • A minimum of 5 years pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology, or a related field

  • Expertise in analyzing cancer genomics datasets including common reference datasets such as TCGA

  • Expertise in bioinformatic analysis of cancer signaling pathways and driver mutations

Specific skills and competencies:

An ideal candidate will be collaborative, self-directed and possess;

  • Demonstrated expertise in Oncology or Immune-Oncology

  • Familiarity with standard methods for bioinformatic data analysis and reference datasets for gene expression, mutations, and related platforms

  • Familiarity with cloud computing for data processing and analysis

  • Proficiency in bioinformatic analysis using R or Python

  • Demonstrated contributions to multi-disciplinary collaborations

  • Strong written and verbal communication skills

Preference will be given to candidates with demonstrated expertise in the areas of clinical genomic analysis and multi-omic data integration

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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