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Sanofi Group Principal Scientist, Biologics and Nanoparticle Process Development in Cambridge, Massachusetts

Position Overview:

Tidal Therapeutics of Sanofi is seeking a highly motivated downstream process development lead. The candidate will support and lead different facets of process development for an entirely new class of therapeutics leveraging targeted lipid nanoparticles containing nucleotides to reprogram cells in vivo (ex. mRNA reprogramming for in vivo generated CART therapy). To help bridge our technology from research to the clinic, the individual would work in close collaboration with formulation development, immunology/pharmacology, protein science and CMC.

Key Responsibilities:

  • Define and optimize overall unit operation sequencing and process parameters.

  • Lead process development studies for the LNPs, targeting moieties and the final drug substance and execute them in multidisciplinary teams.

  • Work with internal partners to efficiently and comprehensively address in-process, stability and compatibility aspects using established assays.

  • Planning, prioritization and initiation of concurrent experimental procedures to ensure their timely completion leveraging internal resources across departments.

  • Work with internal partners to enable seamless tech transfer of processes for clinical readiness.

  • Maintain a strong work ethic and good documentation practices including electronic laboratory notebook maintenance and writing of technical reports and SOPs.

  • Analyze, compile and present results to internal and cross functional teams comprised of members from multiple groups and stakeholders.

  • Develop the near, mid and long-term priorities and platform development activities to enable efficient development for initial products and future pipeline products.

  • Develop and acquire talent to continue to build the team and provide technical mentorship to other team members.

Basic Qualifications:

  • Ph.D. in Chemical or Bioengineering, Chemistry, or closely related field, 7+ years industry, or a Master’s degree and 10+ years industry and a strong technical track record as evidenced by a strong publication record and bringing products to the clinic, title will be commensurate with experience level.

  • Expert in chromatographic techniques including affinity, ion exchange, hydrophobic interaction, mixed-mode, immobilized metal affinity and size exclusion chromatography.

  • Expert in filtration technologies including primary/secondary clarification, normal flow sterile and virus filtration and ultrafiltration/diafiltration (flat sheet and hollow fiber).

  • Experience or knowledge of analytical and biophysical characterization techniques such as SDS-PAGE, SEC, RP-HPLC, CE-SDS, ELISA and DLS.

  • Self-motivated, enthusiastic, well organized, good communicator and results oriented.

  • Ability to excel in an entrepreneurial, dynamic, fast-paced and highly collaborative environment.

Advanced (or Preferred) Qualifications:

  • Experience with downstream processing of mRNA and lipid nanoparticles other nanoparticles.

  • Use of high throughput screening techniques for rapid definition of optimal chromatography operating parameters.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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