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Sanofi Group Manager Immunology & Cell Biology in Cambridge, Massachusetts

The FluNXT team in Cambridge is seeking an experienced, highly motivated and creative Virologist/Immunologist to support the R&D company pipeline objectives. This is a unique position that requires the understanding and application of both existing and new scientific methods and knowledge in accordance with GxP standards. The candidate will be expected to apply expertise across a number of practical skills, including, immunoserology, flow cytometry, cell-based assays, molecular biology and primary cell culture. The scientist will also be responsible to design and optimize relevant in vitro assays to support translational efforts. Experience with laboratory automation equipment and operational knowledge of immunoassay based instruments including Multi-mode plate readers, Octet and Luminex is required. The role is a lab based research scientist who will also be responsible for participating on various teams to design and optimize relevant in vitro assays to support preclinical and clinical evaluation of vaccine candidates. A passion for bench work, data analysis, and reporting excellence is a must. The position will require independent thought and a results-driven attitude while possessing strong and positive communication with different teams.

Key Accountability

  • Participate in design, planning and execution of studies to test immunogenicity, efficacy and safety of viral vaccine candidates

  • Develop and implement novel methods for detailed analysis of humoral and cellular immune responses to vaccine candidates

  • Perform a wide variety of technical procedures and operate a wide variety of lab instrumentation/computer platforms related to Immunology, Virology and Molecular Biology.

  • Support the development and optimization of automation protocols for immune assays: HAI, NT, ELLA, ELISA.

  • Develop and conduct specialized assays and transfer technology to other users.

  • Effectively analyze and summarize experimental outcomes, record experimental procedures and raw and analyzed data.

  • Lead interactions with internal partners in other functional areas, external vendors and external scientific partners, as appropriate

  • Molecular biology support as needed for virus generation or recombinant proteins.

  • Participate in monitoring and maintaining facility related aspects of the lab and lab equipment as needed.

  • Perform statistical analyses on compiled data as needed and present to project teams.

  • Conduct experiments and prepare written reports conforming to defined documentation practices to support of regulatory filings, internal company documents, and external company presentations

  • Prepare and write support manuals, standard operating procedures (SOPs), and validation documents for methods, instruments or work processes.

  • Comply with the company safety policies and minimize risk to self, others and the environment, consistent with the community and industry standards

  • Performs other duties as required

Required Education/Experience:

  • PhD with 2+ years or M.Sc. with 5+ years of relevant experience.

  • Degree should be in Immunology, Virology, Biochemistry or Physical Science or applied science field.

  • Thorough understanding of concepts related to vaccine development against infectious diseases

Preferred Experience:

  • Expertise and extensive knowledge of state-of-the-art principles and theories in immunology, virology and molecular biology

  • Technical expertise with immunological assays: HAI, NT, ELISA, ELLA, MSD, Luminex and FACS

  • Experience with viruses in a BSL II environment is required; experience with influenza is desirable

  • Demonstrated technical proficiency in a broad array of automation based techniques for laboratory experiments.

  • Experience in developing and transitioning laboratory immunoassays into automated high throughput assays is a plus

  • Demonstrated ability to design and execute well thought out assays to provide support and advance pipeline projects

  • Knowledge and experience with Good Research Practice (GRP) and Good Clinical Practice (GCP) regulated laboratory environments

  • Training and experience in assay development.

  • Experience with mammalian cell culture with best practices in tissue culture

  • Experience with primary human cells and tissues

  • Ability to advance multiple projects in a fast paced “biotech like” environment

  • Demonstrated potential to think independently, contribute and collaborate with cross functional project teams, and troubleshoot effectively

  • Communication skills -Able to expresses one’s self clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates with senior management; technical writing skills to support authorship and approval of internal technical documents

  • Organization – Exercises good time management and prioritization skills to balance multiple project and departmental objectives

  • Conversant with ELN for record keeping

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

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